Are you looking for answers for families with unexplained pregnancy loss?

HOPE Website.png

So are we. Stanford, UCSF, and OHSU have teamed up to perform an NIH-sponsored multicenter study to understand genomic predictors of unexplained recurrent pregnancy loss. Eligible subjects must have had two or more losses at any gestation and least one pregnancy of the pregnancy losses was chromosomally normal. Our goal is to identify novel genetic mechanisms for euploid pregnancy loss. Patients are eligible if any pregnancy tissue is available for analysis. Often testing laboratories and pathology departments store tissue for a period of time after testing and this tissue can be ordered and used for our study. Our team will investigate and coordinate all aspects of the study. 

Study activities include collecting DNA from patients and miscarriage tissues some self online questionnaires about medical and pregnancy history, whole genome sequencing of parents and pregnancy tissue, and brief online surveys. Parents and pregnancy tissue (when available) will be sequenced and analyzed for known and novel pregnancy loss genes. Patients may opt to receive results of pathogenic variants and genetic counseling will be provided. Patients planning future pregnancy may be eligible for financial compensation if they are willing to provide additional blood samples before and during pregnancy. Any of our investigators would be happy to talk with you or your staff to provide general information about our experience with miscarriage testing or recurrent pregnancy loss or discuss any aspect of this study.

For providers serving patients who have experienced a miscarriage, the first step for patients is to request additional testing in order to determine if the pregnancy loss was due to aneuploidy. If you have questions about testing recommendations, please contact Dr. Ruth Lathi via email at hopestudy@stanford.edu or via phone at Stanford’s Reproductive and Fertility Center (650) 498-7911.

Feel free to refer patients to this website and display the flyer below in your clinic or practices.

Stanford_Medicine_V-web.png
logo_signature_0.jpeg
unnamed.jpg